Serial bipolar androgen therapy (sBAT) using cyclic supraphysiologic testosterone (STP) to treat metastatic castration-resistant prostate cancer (mCRPC) – Isaacs

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Editorial Commentary


John T. Isaacs1,2, W. Nathaniel Brennen1,2, Samuel R. Denmeade1,2

1Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Brady Urologic Institute, Baltimore, MD, USA;2Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Correspondence to: John T. Isaacs. Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Brady Urologic Institute, Baltimore, MD, USA; Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Email: isaacjo@jhmi.edu.

Provenance: This is an invited article commissioned by the Section Editor, Dr. Peng Zhang, MD, PhD (Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China).

Comment on: Lam HM, Nguyen HM, Labrecque MP, et al. Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a

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Cancer Fighting Diet | MD Anderson Cancer Center

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You can reduce your chances of developing cancer and several chronic diseases by making healthy food choices. A diet rich in plant foods, whole grains and legumes can give your body the range of vitamins, minerals and antioxidants it needs to stay healthy.

Plus, eating a variety of healthy foods can help prevent weight gain and decrease body fat. Maintaining a healthy weight is one of the most important thing you can do to reduce your risk of cancer.

Our experts recommend following the New American Plate guidelines developed by the American Institute for Cancer Research.

You can take the following steps to maintain a healthy diet, manage your weight and reduce your risk of cancer:

  • Eat a plant-based diet. Eating a healthy diet can help you stay lean. Fill 2/3 of your plate with vegetables, whole grains and fruit. Fill the remaining 1/3 or less with lean animal protein
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What to Eat When You Have Cancer

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Yes, food can contribute to cancer. In fact, processed foods – those high in sugar and low in fiber and nutrients – have been linked to higher cancer risk.

But there are healthy options (that taste good, too). We’ll dive into some of the science behind different diets, including plant-based. But the basics are simple: A diet high in fruits, vegetables, and whole grains trumps processed foods.

However, keep in mind that most research only points to associations between diet and cancer, and not necessarily a cause-and-effect relationship.

Foods high in antioxidantsProtects cells from damage caused by free radicals (unstable molecules made by the process of oxidation during normal metabolism). Free radicals may play a part in cancer, heart disease, stroke, and other diseases of aging. Antioxidants include beta-carotene, lycopene, Vitamins A, C, and E, and other natural and manufactured substances. – dark chocolate, pecans, blueberries, strawberries, kale, and

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